ACLY Safeguards Copper Homeostasis to Sustain Brown Adipose Tissue Thermogenesis and Restrain Diet-Induced Obesity.

Research (Wash D C) · 2026 · PMC13150074 · PMID 42109886

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a positive trendno p-value reported

ACLY also showed a positive trend with SCO2 , SLC31A1 , and CCS (Fig.

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an increasing trendno p-value reported

In addition, the cotreatment of primary brown adipocytes with ES and CuCl2 resulted in an increasing trend in the ACLY and UCP1 protein levels (Fig. 2 I), which was contrary to the observations made in vivo (Fig. 2 C).

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