A JAK of two trades: beneficial or adverse effects of Janus kinase inhibition for plasma LDL-cholesterol and major adverse cardiovascular events in inflammatory bowel disease patients?

Curr Opin Lipidol · 2026 · PMC13152051 · PMID 42019047

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a numerical trendno p-value reported

Although some studies report a numerical trend toward higher VTE rates with higher doses of JAK inhibitors, these observations have not reached statistical significance, and absolute event rates remain low [ 51 ].

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