A decision tree model suggests a strong interaction effect between tumor size and a close surgical margin on the prognosis of limb salvage surgery in high-grade osteosarcoma.

Front Surg · 2026 · PMC13153076 · PMID 42112485

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

borderline significantp = 0.06so close (0.05 < p ≤ 0.1)

IIB) (HR = 3.93, p = 0.02), and a tumor diameter >8 cm (HR = 2.38, p = 0.04) were found to correlate with worse overall survival post-surgery in the univariate analysis, with PTA still significant ( p < 0.05) and Enneking staging borderline significant ( p = 0.06) in the multivariate model. 3.2.

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