Real-world management and long-term outcomes in adolescent, young adult, and adult medulloblastoma: Experience from a monocentric series with multimodal and targeted approaches.

4 However, recent evidence suggests that the survival advantage of gross total resection (GTR) over near-total resection (NTR) may not be significant, particularly in SHH-activated and WNT subgroups, despite the traditional association between GTR and enhanced survival, particularly in historical cohorts. 4 , 15 Therefore, while the standard of care should be the maximal safe resection, the surgical removal of small residual portions of the tumor is not advisable when the risk of neurological morbidity is high.

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