Barely Significant
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Global burden of lower extremity peripheral arterial disease attributable to smoking from 1990 to 2021: A secondary dataset analysis of the Global Burden of Disease Study 2021.

Tob Induc Dis · 2026 · PMC13154163 · PMID 42111955

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a decreasing trendno p-value reported
Conversely, countries with high SDI values (typically >0.75) mostly exhibited a decreasing trend (EAPC <0).

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an increasing trendno p-value reported
The polynomial regression fitting curves (black lines) for both mortality and DALYs demonstrated that countries with low SDI values (typically <0.7) predominantly experienced an increasing trend in disease burden (EAPC >0).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.