Oncological Outcomes of Salvage Oropharyngectomy in Irradiated Neck for Recurrent or Metachronous Squamous Cell Carcinoma.

Head Neck · 2026 · PMC13155182 · PMID 41612947

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0960

boldest claim

The sentences

at the limit of significancep = 0.053so close (0.05 < p ≤ 0.1)

In multivariable analysis, only the following variables remained significant: pT status ≥ 3 (HR 5.24 [95% CI 2.41–11.39]; p < 0.001) and metachronous OPSCC (HR 0.32 [95% CI 0.14–0.72]; p = 0.006), with cN+ status at the limit of significance (HR 2.31 [95% CI 0.99–5.41]; p = 0.053) (Table 5 ).

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a statistical trendp = 0.096so close (0.05 < p ≤ 0.1)

In univariable analysis, factors significantly associated with worse OS were cN+ status (HR 2.11 [95% CI = 1.19–3.73]; p = 0.009), pT status ≥ 3 (HR 2.27 [95% CI 1.27–4.07]; p = 0.005), as well as a statistical trend for pN+ status (vs. pN0/pNx, HR 1.73 [95% CI 0.90–3.32]; p = 0.096) and older age at surgery (HR 1.03 [95% CI 1.00–1.06]; p = 0.095).

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