Targeted analysis of KRAS and CREBBP mutations uncovers a potential population-specific signature in thai patients with liver fluke-associated cholangiocarcinoma.

PLoS One · 2026 · PMC13155607 · PMID 42102112

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0680

boldest claim

The sentences

highly significantP < 0.001actually significant

KRAS codon 13 polymorphisms were identified in 21.4% of iCCA patients, were absent in OV cases, and were present in 17.5% of healthy controls, demonstrating a highly significant difference (P < 0.001).

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a trend toward significanceP = 0.068so close (0.05 < p ≤ 0.1)

showed a trendP = 0.068so close (0.05 < p ≤ 0.1)

Furthermore, ordinal regression analysis used to predict tumor stage indicated that metastasis was the only highly significant factor (P < 0.001), while tumor size showed a trend toward significance (P = 0.068). 3.5.

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