Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in <i>Drosophila</i>.

The data, quantified in Figure 4B, demonstrates a highly significant, age-dependent increase in nuclear H3K9me3 integrated density in control OPNs (p=0.0014), an effect that was completely abrogated in aged flies with OPN-specific knockdown of dSetdb1 (p>0.9999).The consistency between the global changes observed in whole-head lysates (Figure 2A) and the specific, quantitative changes measured within the relevant neuronal nuclei (Figure 4B) provides strong, convergent evidence for our conclusion that dSetdb1 mediates an age-dependent increase in H3K9 trimethylation.

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