A novel green QbD-optimized RP-HPLC bioanalytical method for the simultaneous determination of doxorubicin and rifampicin in human plasma.

BMC Chem · 2026 · PMC13156879 · PMID 42104397

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extremely significantno p-value reported

It was shown that the pH of buffer was an extremely important parameter impacting A and T 10% of DOX, while an extremely significant parameter influencing Rt of DOX and Rt of RFP was % acetonitrile, as illustrated by Figures S1, S2, and S3 for Pareto charts, main effect plots, and interaction plots, respectively.

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