A glial oxidative signature predicts disability in primary progressive multiple sclerosis and is associated with long-term cognitive decline.

Baseline IL-6 ( Table 4 , down) showed a borderline significant positive association with attention at baseline (TMT-A: β = 0.360, p = 0.050), which persisted as a trend at 5 years (β = 0.996, p = 0.052) and reached significance at 10 years (β = 0.568, p = 0.020).

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