Efficacy and Safety of Quadruple Therapy With Semisynthetic Tetracycline for Helicobacter pylori Eradication: A Meta-Analysis.

J Gastroenterol Hepatol · 2026 · PMC13158637 · PMID 41852181

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marginally statistically significantp = 0.05actually significant

Compared with the control group, the semisynthetic tetracycline‐containing quadruple regimen with a 14‐day duration demonstrated a marginally statistically significant difference in the eradication rate (OR = 1.34, 95% CI: 1.01–1.79; p = 0.05), thus suggesting that the 14‐day course may have a certain role in improving eradication efficacy; however, the results should be interpreted with caution.

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