A specific stem cell program and CD112 immunological axis dysfunctions underpinning monosomy 7-associated myeloid neoplasms.

Signal Transduct Target Ther · 2026 · PMC13161220 · PMID 42115611

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borderline significanceno p-value reported

41 Our RNA-seq showed IKZF1 downregulation at borderline significance (log 2 fold change = −0.938 and FDR = 0.001), while qRT-PCR in a larger cohort of monosomy 7 ( n = 31), clearly showed significant IKZF1 downregulation (Fig. 4a ).

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