Efficacy and safety of ATRA plus arsenic trioxide versus ATRA plus chemotherapy in newly diagnosed acute promyelocytic leukemia: a grade-assessed systematic review and meta-analysis.

BMC Cancer · 2026 · PMC13162355 · PMID 41906112

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borderline significantno p-value reported

And a pooled analysis of 5 studies resulted in a risk ratio of 3.79 (95% confidence interval 1.00-14.36; P < 0.05), which corresponds to a borderline significant increase with moderate heterogeneity (I2 = 61%; Supplementary Fig. 10).

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