Normoxic HIFα-mediated metabolic rewiring in cancer as a novel therapeutic target of tumor heterogeneity.

While we observed differences in α-KG, glutamate and proline metabolite synthesis between HIF1α and HIF2α KO NSCLC cells, both models showed increased synthesis of the TCA cycle metabolites citrate, malate, and a highly significant 3-fold increase of succinate synthesis compared to HIF WT control cells (Fig. 2 E).

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