Fucosylation Dynamics as a Critical Determinant of Cancer Cell Fate in Colorectal Carcinoma: Integrating Hallmark Plasticity, Microenvironmental Remodelling, and Therapeutic Resistance.

All three EDI metrics demonstrated highly significant associations with fucosylation status ( Figure 1 A, Table 1 ).

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Critically, activating invasion and metastasis hallmarks were completely absent—EMT was not significant ( p = 0.085), extracellular matrix organization showed no enrichment, and all invasion-related pathways failed to reach significance, providing pathway-level validation of their non-aggressive behaviour.

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Enabling replicative immortality showed only borderline significance, limited to mitotic G1 phase transition, with no enrichment of E2F targets, Myc targets, or G2-M checkpoint pathways, consistent with a quiescent or slow-cycling differentiated phenotype ( Table S6: Supplementary Materials S6 , Figure 6 E,F). 3.5.3.

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