When the inoculation dose was increased to the middle dose of 2 × 10 5 IFUs, WtCm’s peak shedding was advanced to day 5, resulting in a highly significant difference in shedding level between WtCm and intrOv, which continued to day 14 post-inoculation.
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The oral vaccine intrOv is attenuated in infecting the lower airway and inducing chronic pathology.
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