However, in the SN ipsilateral to lesion, there were highly significant increases in extracellular DA in the SN after K + -infusion in striatum (F(1,11) = 27.9, p = 0.0003; Figure 6 F), with extracellular DA increasing by ~7-fold within the first 20 min.
There was a substantial effect of time after infusion (F (2,18) = 50.8, p < 0.0001), but time after lesion or sham-operation was not a significant factor (F (1,9) = 1.0, p = 0.34), nor were there differences between extracellular DA levels contralateral to lesion v sham-operation group, although there was a notable trend toward an increase in striatum contralateral to lesion (F (1,9) = 4.1, p = 0.073).