marginally significantP = 0.05
Sensitivity Analysis Using Self-Reported Glaucoma Definition When glaucoma was defined solely by self-reported physician diagnosis (167 cases, 2785 controls), a marginally significant association with higher serum Klotho levels was observed (OR = 1.05 per 100 pg/mL increase; 95% CI, 1.00–1.10; P = 0.05 in both models).