Formulation of Metformin-Loaded Chitosan Nanoparticles and In Vivo Evaluation of Its Hypoglycemic Effects.

Pairwise comparisons revealed that the increase from 50 to 100 μg/mL was highly significant ( p < 0.01), while further increases from 100 to 200 μg/mL and from 200 to 300 μg/mL remained statistically significant ( p < 0.05).

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However, marginally significant differences were observed between the formulations MN1, MN2, and MN3, with p -values of 0.0525 at pH 7.4 and 0.053 at pH 2, suggesting a consistent trend toward higher cumulative release from MN3 under both conditions.

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