Process Optimization of Novel Boronophenylalanine Liposomes Through Box-Behnken Response Surface Design and Preliminary Evaluation in A549 Lung Carcinoma Cells for Boron Neutron Capture Therapy.

Multiple regression analysis was performed using the quadratic polynomial model described by Equation (1), linking the independent variables to EE response: (1) Y = 56.32 + 0.5366 X 1 + 1.73 X 2 − 0.2654 X 3 − 0.4980 X 1 X 2 + 0.5468 X 1 X 3 + 0.0390 X 2 X 3 − 8.95 X 1 2 - 6.52 X 2 2 − 5.14 X 3 2 Analysis of variance for the regression model ( Table 2 ) revealed that the model exhibited a highly significant F-value of 830.28 ( p = 0.0001).

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