Sedentary behavior, physical activity, psychological well-being, and gynecologic and obstetric disorders: A multivariable Mendelian randomization and mediation analysis.

Medicine (Baltimore) · 2026 · PMC13166659 · PMID 42116317

Europe PMC DOI

hedged sentence

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantP = 5.50 × 10 −8actually significant

However, this association is provisionally retained because the MR-PRESSO global test for pleiotropy was highly significant ( P = 5.50 × 10 −8 ), and the outlier-corrected estimate remained significant and directionally consistent with the primary IVW analysis (OR 0.41, 95% CI: 0.31–0.54).

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