Dynamic serum metabolomic changes during Chinese herbal hot compress therapy for postpartum uterine involution: pathway analysis and candidate biomarker identification.

As treatment progressed, the between-group differences became progressively significant: at T1, LysoPC(18:1) and arachidonic acid showed significant differences ( p < 0.01), while L-tryptophan and citric acid reached p < 0.05, and at T2, all four biomarkers showed highly significant between-group differences (LysoPC(18:1) and arachidonic acid: p < 0.001; L-tryptophan and citric acid: p < 0.01).

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These results suggested that CHHC therapy was associated with specific changes in the serum metabolic profiles of patients with postpartum uterine subinvolution, and these changes progressively intensified with treatment duration, with between-group differences showing an increasing trend from T0 → T1 → T2. 3.3.

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