The MTHFR C677T polymorphism and protection against Legg-Calvé-Perthes disease in children: an updated systematic review and meta-analysis.

Orphanet J Rare Dis · 2026 · PMC13173826 · PMID 41933355

Europe PMC DOI

hedged sentences

0.0440

closest p · 0.9× alpha

0.0620

boldest claim

The sentences

marginally significantp = 0.044actually significant

TT + CC) was marginally significant (OR = 0.639, 95% CI: 0.415–0.984, HKSJ p = 0.044; Fig. 2 D), with zero heterogeneity.

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did not achieve significancep = 0.062so close (0.05 < p ≤ 0.1)

C) did not achieve significance under HKSJ adjustment (OR = 0.711, 95% CI: 0.492–1.026, HKSJ p = 0.062; Fig. 2 A), though the direction was protective.

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