Cerebrovascular-CSF coupling measured by broadband near-infrared spectroscopy as a physiological marker of brain aging and Alzheimer's disease.

Front Aging Neurosci · 2026 · PMC13176143 · PMID 42147463

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

marginally significantp = 0.053so close (0.05 < p ≤ 0.1)

Similarly, the correlation slopes of the AD patients were significantly more negative than those of healthy OA in the E/N bands and marginally significant ( p = 0.053) in the M band.

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highly significantno p-value reported

After applying Bonferroni correction to control for multiple comparisons across the three groups, the differences in coupling metrics between YA and patients with AD remained highly significant.

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