Targeting lineage-specific heterogeneity and hypovascular-fibrotic barriers may enable precision immunotherapy in pituitary neuroendocrine tumors.

Front Immunol · 2026 · PMC13176185 · PMID 42148075

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a decreasing trendno p-value reported

For example, vitronectin, which is absent in the normal pituitary gland, appears in the tumor microenvironment, while the content of laminin, which has an inhibitory effect on tumor cell proliferation, shows a decreasing trend ( 49 ).

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