Integrated Germline and Somatic Molecular Profiling to Detect Cancer Predisposition Has a High Clinical Impact in Poor-Prognosis Pediatric Cancer.

Using the ProxECAT method ( 33 ), we identified a highly significant enrichment of predicted disruptive variation across the 59 CPGs that passed data quality filters in both cohorts (normalized variant burden in PRISM/normalized variant burden in gnomAD = 2.44; P = 1.7 × 10 -7 ).

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