highly significantp = 0.001
In the fully adjusted Model 3: RNFL Rate = −1.21 − 0.147 × ISI + 0.014 × Age − 0.132 × Sex male − 0.747 × Untreated ISI remained highly significant (β = -0.147, SE = 0.041, p = 0.001), with each unit increase predicting 0.147 μm/year faster progression ( Fig. 2 ).