Genetic variants in the leptin-melanocortin pathway and their joint effects with physical activity and sleep duration on risk of childhood obesity.

PLoS One · 2026 · PMC13178977 · PMID 42139370

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marginally significantno p-value reported

Associations between genetic variants in the leptin-melanocortin pathway and obesity risk Most genetic variants in controls were confirmed to follow HWE, with the exception of rs3746619 in MC3R , which showed a marginally significant departure after permutation correction ( P permutation = 0.046, S1 Table ).

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