Dualsteric Agonist for M2 Muscarinic Receptor Causes Oxidative Stress and Mitochondrial Alteration in Human Glioblastoma Cancer Stem Cells.

J Neurochem · 2026 · PMC13179530 · PMID 42141821

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a decreasing trendno p-value reported

As shown in Figure 4b , in U251 cells the stimulation of M2 mAChR by N‐8‐Iper induced a significant reduction in basal mitochondrial respiration and in mitochondrial ATP production; moreover, only the high dose induced a significant effect on spare respiratory capacity, even though at low dose a decreasing trend was observed.

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