Secretory Lysosome-Related Gene Signature Defines the Immune Microenvironment and Identifies RGS2 as a Prometastatic Factor in Hepatocellular Carcinoma.

Hum Mutat · 2026 · PMC13179717 · PMID 42147807

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an increasing trendno p-value reported

Discussion The incidence of liver cancer has shown an increasing trend [ 29 ], and the great majority of diagnoses and fatalities from liver cancer (45%) are due to HCC.

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highly significantno p-value reported

We observed that immLysoS scores exhibited a highly significant negative correlation with the populations of immune cells that support tumor killing, such as activated CD8 T cells and activated B cells.

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