Overcoming resistance in lung cancer: combined mitochondrial destabilization by lipophilic cations and doxycycline in hypoxic non-small cell lung carcinoma.

Front Pharmacol · 2026 · PMC13180888 · PMID 42158945

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At 24 h, IC 50 values for TPP + C 10 , GA–TPP + C 10 , PA–TPP + C 10 and SA–TPP + C 10 tended to be higher in fibroblasts than in tumor cells, suggesting a possible trend toward lower early cytotoxicity in non-cancerous cells.

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