CMML2AML: machine-learning discovery of co-mutations and specific single mutations predictive of blast transformation in chronic myelomonocytic leukemia.

Blood Cancer J · 2026 · PMC13181037 · PMID 41965730

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borderline significanceno p-value reported

Similar MVA in the Italian cohort confirmed the independent significance of NRAS + SETBP1 (HR 3.3; p = 0.01), NPM1 (HR 7.8; p < 0.01), ASXL1 (HR 1.6; p = 0.04) and CMML-2 (HR 2.8; p < 0.01, while BCOR (HR 2.3; p = 0.1) and ASXL1 + RUNX1 (HR 1.6; p = 0.16) demonstrated borderline significance, suggesting that the contribution of these signatures is modified by accompanying clinical variables (Table 2 ).

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