LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC.

Nat Commun · 2026 · PMC13181136 · PMID 41881985

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0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

borderline significanceP = 0.06so close (0.05 < p ≤ 0.1)

RT-qPCR confirmed induction of NOTCH/TGF‐β‐pathway genes ( NOTCH1 , HES1 , TGFB2 , TGFBR2 , and ID3 ) and reduction of ASCL1 and DLL3 , with some markers showing borderline significance (e.g., TGFBR2 P = 0.06) (Fig. 9j and Supplementary Fig. 18h, l ).

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