Acute respiratory distress vs healthy lung environments differently affect mesenchymal stromal cell extracellular vesicle miRNAs.

Although recent meta-analyses demonstrate an overall trend towards efficacy [ 14 – 16 ] and a secondary analysis of one double blind, randomized clinical trial reported evidence of favorable biologic effects on levels of inflammatory mediators in the bronchoalveolar lavage fluid (BALF) comparing patients who received MSCs versus placebo [ 17 ].

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