The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding "ZZ" domain.

Genetics · 2026 · PMC13181410 · PMID 41206465

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0.0620

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

just missing significanceP = 0.062so close (0.05 < p ≤ 0.1)

Consistent with the SMG analyses, ORB2 targets coregulated (or not) by BRAT and PUM exhibited a similar trend but with the ORB2-only targets just missing significance ( P = 0.062 and 0.073 for the PUM and BRAT comparisons, respectively; Supplementary Figs. 11 and 12 ).

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