Identification of a genetic locus responsible for the dominant white-spotting coat phenotype in mice spontaneously isolated from a Japanese wild-derived inbred strain.

In contrast, 12 of the 43 (B6× Ads )F 2 progeny exhibited the white-spotting phenotype, showing a highly significant deviation from the expected 2:1 ratio for a simple autosomal dominant inheritance pattern with homozygous embryonic lethality (χ 2 =29.07, P <0.0001).

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