Long term administration of selective NMDA GluN2B receptor blocker Ro25-6981 attenuates neurodegeneration in mouse model of spinocerebellar ataxia type 1 (SCA1).

ATXN1[Q85]-expressing mice were not different to other groups for the first 3–4 weeks but afterwards exhibited a gradual impairment in motor coordination, which became highly significant by the eighth week, likely reflecting gradual destruction of the cerebellum (see below).

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