Barely Significant
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A Real-World Study of Polynucleotides HPT for Treating Periorbital Hyperpigmentation.

Clin Cosmet Investig Dermatol · 2026 · PMC13186231 · PMID 42164086

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The sentences

highly significantp <0.001actually significant
Results Regarding the primary endpoint, the overall picture showed a generalized, highly significant shift toward less severe periorbital hyperpigmentation (p <0.001), especially among needle-treated subjects with the structural subtype.

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