Quantification of anti-BDNF immunofluorescence intensity using an antibody able to recognize both mature and pro-BDNF, subtracted from the background of each image, revealed a highly significant increase in endogenous BDNF expression levels in both somata and dendrites following three days of treatment with either SINEUP-PAN or SINEUP-Ex1 with substantially equivalent effects of the two SINEUP constructs.
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Long non-coding SINEUP RNA enhancing BDNF translation prevents dendritic atrophy following an Aβ-peptide challenge.
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