Loss of salivary agglutinin induces changes in the salivary microbiome and accelerates development of oral cancer.

Microbiome · 2026 · PMC13188527 · PMID 41964098

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Notably, the identification of OTUs belonging to Sphingomonas (OTU0054) and Lachnospiraceae (OTU0318) as differentially abundant between Dmbt1 −/− and Dmbt1 + / + and between precancer and OSCC diagnoses by both LSVCMM and fPCA analyses suggests that these OTUs may be significant for OSCC development and possibly regulated in some way by DMBT1.

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