Exercise and tissue-resident memory T cells: from circulating numbers to spatial immune remodeling.

Front Immunol · 2026 · PMC13189724 · PMID 42183211

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In some tissues, IL-7 is involved in the maintenance of T RM cells, but its contribution is not as significant as IL-15 ( 42 ). 2.4 Tissue-specific heterogeneity The T RM cells are characterized by a stunning functionality and phenotype that is adjusted to the residing tissues, which is the result of the individual needs and signals of each microenvironment ( Table 2 ).

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