PD-1-targeted therapeutic strategies for advanced or recurrent gastric and gastroesophageal junction cancer: a systematic review and network meta-analysis.

Transl Cancer Res · 2026 · PMC13191019 · PMID 42180907

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a favorable trendno p-value reported

For example, the KEYNOTE-061 trial, which evaluated pembrolizumab monotherapy versus paclitaxel in previously treated gastric cancer, failed to demonstrate a significant improvement in PFS or ORR, despite showing a favorable trend in OS among patients with high PD-L1 expression (CPS ≥10) ( 30 ).

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