The pachytene-specific lncRNA <i>1700008K24Rik</i> is essential for mouse spermatogenesis and functions as a conserved piRNA precursor.

∗ P < 0.05 indicates a significant difference, ∗∗ P < 0.01 indicates a highly significant difference, ∗∗∗ P < 0.001 indicates an extremely significant difference, and NS represents no significant difference. 3 Results 3.1 1700008K24Rik is a pachytene-specific lncRNA dynamically regulated during spermatogenesis We first characterized the genomic features of 1700008K24Rik .

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This specific induction was corroborated by small RNA-seq (GEO: CRA028834) on GC-2 spd(ts) cells overexpressing 1700008K24Rik , which showed that there was an increasing trend in the expression levels of the 1700008K24Rik -related piRNAs ( Fig. 2 E, Fig.

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