highly significantP < 0.01
All statistical tests were two-sided, with P < 0.05 considered to be a statistically significant difference, and it is considered to be a statistically highly significant difference when P < 0.01.
All statistical tests were two-sided, with P < 0.05 considered to be a statistically significant difference, and it is considered to be a statistically highly significant difference when P < 0.01.