Aerobic glycolysis-driven lactate accumulation and acidic tumor microenvironment in hepatocellular carcinoma: a vicious cycle promoting tumor progression.

Front Pharmacol · 2026 · PMC13193873 · PMID 42181875

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

highly significantno p-value reported

Analysis of gut microbiota in HCC patients has revealed that diverse bacterial flora, such as Clostridium , can modulate the TME, proving highly significant in the development of HCC ( Zuo et al., 2025 ).

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.