Serum and cerebrospinal fluid neuroinflammatory biomarkers and trimethylamine N-oxide: associations with white matter lesion severity.

Front Immunol · 2026 · PMC13193994 · PMID 42183298

Europe PMC DOI

hedged sentence

0.0450

closest p · 0.9× alpha

0.0450

boldest claim

The sentences

marginal significanceP = 0.045actually significant

Regarding IgG, while univariate analysis showed marginal significance in CSF (P = 0.045), FDR correction rendered this non-significant (q=0.12), and no significant correlation was found with Fazekas grade (P = 0.068), suggesting limited association with WML severity in this cohort.

also in 5,069 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.