ACAA1 mediates arachidonic acid dysregulation and membrane phospholipid remodeling to promote crystal-cell adhesion and ferroptosis susceptibility in calcium oxalate kidney stone.

J Pharm Anal · 2026 · PMC13195540 · PMID 42181662

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an increasing trendno p-value reported

Certain metabolites from the downstream LOX and CYP450 pathways of AA showed a significant decrease, while downstream products of the CYP pathway exhibited an increasing trend ( Figs. 3 N and S2J ).

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a decreasing trendno p-value reported

Overexpression of ACAA1 resulted in a decreasing trend in AA and some of its downstream metabolites ( Fig. 3 M).

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