Conversely, the repertoire of upregulated (Recurrent RD/No Recurrent RD ratio) and Recurrent RD-exclusive proteins revealed a highly significant functional signature pertaining to the pathologic conditions (PPI enrichment P -value = 0.00269).
Rhegmatogenous retinal detachment (RD) is a severe ocular condition whose incidence is reported between 10 to 17/100,000 cases per year with an increasing trend in the past decades. 1 – 4 Recurrent retinal detachment (Recurrent RD) develops in 18% to 22% of patients undergoing primary repair 5 – 7 and retains a guarded prognosis in a relevant proportion of affected patients, potentially leading to blindness. 8 Proliferative vitreoretinopathy (PVR) is the p