Glucagon-Like Peptide-1 Receptor Agonists in Hip and Knee Arthroplasty: A Comprehensive Systematic Review and Meta-Analysis of Perioperative and Postoperative Outcomes.

Arthroplast Today · 2026 · PMC13197706 · PMID 42182892

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a nonsignificant trendno p-value reported

At 90 days, we observed a nonsignificant trend toward higher PPF rates among GLP-1RA users (OR: 1.65; 95% CI: 0.97–2.81), which progressed to a statistically significant elevation by 1 year (OR: 2.06; 95% CI: 1.17–3.62), driven primarily by TKA, with no clear effect in THA.

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