An LC-MS/MS Method for Simultaneous Determination of Almonertinib and Atorvastatin: Evaluating Their Drug-Drug Interactions in Rat.

Compared with single administration of almonertinib (Group 1), co-administration with atorvastatin significantly increased almonertinib’s C max , AUC 0-t , and AUC 0-∞ by 1.21, 2.20 and 4.01-fold, respectively, and prolonged the half-life time of almonertinib (all P<0.05), while obviously decreased CL z /F by 66.3% (P < 0.05), and the V z /F of almonertinib also showed a decreasing trend.

also in 47,180 other papers